Clinical Evidence Current Studies
Current studies
| Short title |
Project title |
Principal coordinating investigator |
Project ending |
Current phase |
| MRONJ registry |
An international, multicenter, prospective registry to collect data of treatment patterns of patients with Medication-Related OsteoNecrosis of the Jaw (MRONJ) and their outcome |
Risto Kontion, Sven Otto |
2026 |
Monitoring |
| BCFx registry |
International, multicenter, prospective registry to collect data of treatment patterns in patients with bilateral condylar fracture (BCFx) of the mandible |
Risto Kontio, Edward Ellis 3rd |
2025 |
Analysis |
| OFx |
International, multicenter, prospective registry to collect data on orbital fractures (OFx), their treatment and outcome |
Eppo B Wolvius |
2029 |
Monitoring |
| TMJ replacements |
International, multicenter, prospective registry to collect data of patients treated with alloplastic temporomandibular joint (TMJ) replacements |
Andreas Thor |
2031 |
Monitoring |
| Short title |
Project title |
Principal coordinating investigator |
Project ending |
Current phase |
| Fracture Monitor |
Prospective case series to analyze safety data in femoral and proximal tibial fracture patients treated with a locking compression plate with an attached investigational Fracture Monitor (Fracture Monitor-Femur/Proximal Tibia) |
Bendikt Braun |
2026 |
Monitoring |
| (Image AI) | Development of a high quality, annotated data set of proximal femur fractures (31A/31B/31C) to be used for development or testing of AI |
Alessandro Aprato |
2025 | Monitoring |
| Short title |
Project title |
Principal coordinating investigator |
Project ending |
Current phase |
| Immpact |
Development of performance metrics for cephalomedullary nailing for unstable pertrochanteric fractures- phase 1 |
Anthony Gallagher |
n/a |
Analysis |
| Short title |
Project title |
Principal coordinating investigator |
Project ending |
Current phase |
| EPOSO |
The epidemiology, process and outcomes of spine oncology |
Charles Fisher |
2024 |
Publication |
| SDIM |
Spinal deformity intraoperative monitoring: understanding and managing intraoperative neuromonitoring changes during spinal deformity surgery |
Stephen Lewis |
2023 |
Analysis |
| PEEDS |
Prospective evaluation of elderly deformity surgery |
Stephen Lewis |
2025 |
Analysis |
| MTRON |
Metastatic tumor research and outcomes network: a multicenter prospective registry for the management of metastatic spine tumors |
Charles Fisher |
open ended registry |
Monitoring |
| PTRON |
Primary tumor research and outcomes network: A multicenter prospective registry for the management of primary tumors of the spine |
Jeremy Reynolds |
open ended registry |
Monitoring |
| DegenPRO |
Spine registry to collect outcome measures related to the disease status of patients with dpine disorders |
Tim Yoon |
2024 |
Monitoring |
| Spine_TL-A3-A4 |
Thoracolumbar burst fractures (AOSpine A3, A4) in neurologically intact patients: an observational, multicenter cohort study comparing surgical versus non-surgical treatment |
Marcel Dvorak |
2025 |
Analysis |
| SCI POEM |
Prognostic factors and therapeutic effects of surgical treatment for traumatic spinal column iInjury with spinal cord injury |
Allard Hosman |
2025 |
Publication |
| INTWIN |
Traumatic incomplete tetraplegia without instability: a prospective multicenter feasibility study of outcomes and prognosis |
Jefferson R Wilson |
2027 |
Planning |
| I-SCRIBBLE |
Spinal Cord Injury Blood Biomarker Longitudinal Evaluation |
Brian K. Kwon |
2028 | Idea |
| SMART |
Durability of supplementary rod constructs—SuppleMentAry Rod Technique (SMART)—for long-segment posterior instrumented spinal fusion procedures: A multicenter retrospective comparative study with dual-rod constructs |
Justin Smith |
2027 | Planning |
| TL Ofx |
The osteoporotic fracture classification-based scoring system for treatment decision in thoracolumbar osteoporotic fractures: An international multicenter prospective study |
Klaus Schnake |
2028 | Idea |
| Short title |
Project title |
Principal coordinating investigator |
Project ending |
Current phase |
| TROLLEY |
Evaluation of a growth guiding construct vs. standard dual growing rods and VEPTR for the treatment of early onset scoliosis patients: A prospective multi-center cohort study with a matched historical control. |
Jean Ouellet, MD, FRCSC |
2029 | Monitoring |
| Moticon - HTO |
OpenGo Sensor Insole in open wedge HTO |
Steffen Schröter |
Q2 2024 |
Monitoring |
| PedFemFx |
A prospective multicenter observational registry for children up to 16 years of age with femur shaft fractures |
Peter Schmittenbecher, Unni Narayanan |
2024 |
Analysis |
| FR FNS |
A focused registry on the Femoral Neck System (FNS) in patients with femoral neck fractures |
Karl Stoffel |
2024 |
Analysis |
| EPOCA |
A randomized multicenter study comparing the effectiveness of hemi versus total shoulder arthroplasty in patients with a degenerative joint disease |
Norbert Suedkamp, Martin Jäger |
Q2 2024 |
Analysis |
| PPFx Registry |
Multicenter prospective registry for periprosthetic fractures after hip or knee arthroplasty |
Karl Stoffel |
2028 |
Monitoring |
| VA-LCP Case review |
Locking plates for distal femur fractures – a multicenter case review A retrospective radiological analysis of the mechanical performance of different locking plates in distal femoral fractures |
Mark Lee |
2024 |
Analysis |
| LoBoDeRe |
An international, multicenter, prospective registry to investigate treatment options and their outcomes on Long Bones Defects |
Hans-Christoph Pape |
2029 |
Planning |
| FROST |
Fracture-Related Outcome Study for operatively treated Tibia shaft fractures |
Willem-Jan Metsemakers |
2027 |
Monitoring |
| SMDR Registry | International, multicenter, prospective registry to collect data on treatment, outcome, and complications subsequent to reconstruction of acquired segmental mandibular defects in oral squamous cell carcinoma patients - SMDR (Segmental Mandibular Defect Reconstruction) registry |
Rüdiger M Zimmerer | 2030 | Monitoring |
| MatrixWAVE |
An International, Multicenter, Focused Registry to collect clinical data on the MatrixWAVE Mandibulo-Maxillary Fixation System |
Carl-Peter Cornelius |
2025 | Monitoring |
| VA Clavicle | Observational case series on the clinical performance of the DePuy Synthes Variable Angle Clavicle Plate and Clavicle Hook Plate 2.7 Systems |
Simon Lambert | 2027 |
Planning |
| Short title |
Project title |
Principal coordinating investigator |
Project ending |
Current phase |
| PPFx Registry |
Multicenter prospective registry for periprosthetic fractures after hip or knee arthroplasty |
Karl Stoffel |
2023 |
Monitoring |
| CPP Patient Outcome Project I |
Clinical Priority Program (CPP) Patient Outcome Project I: |
Marilyn Heng, Claudia Hartmann |
2024 |
Publication |
| CPP Patient Outcome Project II |
Clinical Priority Program (CPP Patient Outcome Project II: |
Tim Pohlemann, Benedikt Braun |
2029 |
Monitoring |
| CPP Patient Outcome Project III |
Clinical Priority Program (CPP) Patient Outcome Project III: |
Prakash Jayakumar, Marilyn Heng, Stephen Gwilym |
2029 |
Monitoring |
| CPP Patient Outcome Project IV |
Clinical Priority Program (CPP) Patient Outcome Project IV: |
Marilyn Heng (center 1), |
2029 |
Monitoring |
| AOFFP | Fragility Fractures of the Pelvis: Observational Outcome Study | Pol Maria Rommens | 2029 | Monitoring |
| PedOrtho | A prospective multicenter observational registry of pediatric orthopedic trauma and health outcomes in skeletally immature children | Kishore Mulpuri | 2028 | Monitoring |
| (COSTA 2) | Two-stage development of a Core Outcome Set for distal tibia and ankle fractures. COSTA 2, the second stage, seeks to identify the best suitable outcome measurement systems attributed to the defined core domain sets | Kirstie Haywood | 2025 | Planning |